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時間 期刊名 IF 文章標(biāo)題 方法 物種 來源
1 2015 Lancet 88.5 HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials 遺傳學(xué)研究、他汀類藥物試驗Meta 分析 人 doi:10.1016/S0140- 6736(14)61183-1
2 2022 Nature 48.5 Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage RRBS、微量WGBS
scATAC-seq、 SMART-seq2 		人體胚胎細(xì)胞 https://doi.org/10.1038/s41586- 022-04625-0
3 2009 Science 45.8 Complete resequencing of 40 genomes reveals domestication events and genes in silkworm (Bombyx) 全基因組重測序 家蠶 doi:10.1126/science.1176620
4 2023 Cell 42.5 Live birth of chimeric monkey with high contribution from embryonic stem cells 微量WGBS、SMART-seq2 食蟹猴 DOI:10.1016/j.cell.2023.10.005
5 2025 Molecular Cancer 33.9 NSUN2-mediated cytosine-5 methylation of FSP1 protects acute myeloid leukemia cells from ferroptosis RNA-BS 人 細(xì)胞 doi:10.1186/s12943-025-02394-8
6 2017 Cell Res 25.9 De novo DNA methylation during monkey pre-implantation embryogenesis 微量WGBS 恒河猴，胚胎細(xì)胞 DOI:10.1038/cr.2017.25
7 2014 BLOOD 23.1 Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1 WES、孟德爾遺傳分析、 qPCR、qRT-PCR、ChIP 人，外周血 DOI:10.1182/blood-2014-08- 596445
8 2025 Cell Stem Cell 20.4 Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts RRBS 人體胚胎細(xì)胞 doi:10.1016/j.stem.2024.12.010
9 2025 Molecular Cell 16.6 DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation RNA-BS、RNA-seq、RRBS 小鼠 細(xì)胞 doi:10.1016/j.molcel.2025.04.019
10 2024 ACS Nano 16 Genome-Wide Molecular Adaptation in Algal Primary Productivity Induced by Prolonged Exposure to Environmentally Realistic Concentration of Nanoplastics WGBS、RNA-seq 小球藻 DOI:10.1021/acsnano.4c09709
11 2024 Nat Commun 15.7 Reprogramming mechanism dissection and trophoblast replacement application in monkey somatic cell nuclear transfer scWGBS、微量WGBS 恒河猴 DOI:10.1038/s41467-023-43985-7
12 2024 Nat Commun 15.7 Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma ChIP-seq 人、小鼠頭頸鱗癌細(xì)胞 DOI:10.1038/s41467-024-52981-4
13 2024 Nat Commun 15.7 Non-invasive modulation of meningeal lymphatics
ameliorates ageing and Alzheimer's disease-associated pathology and cognition in mice 		Smart-seq2 小鼠腦膜組織 doi: 10.1038/s41467-024- 45656-7
14 2024 Nat Commun 15.7 Allosteric regulation by c-di-AMP modulates a complete N-acetylglucosamine signaling cascade in Saccharopolyspora erythraea EMSA 、ChIP-seq、qRT- PCR 細(xì)菌 doi: 10.1038/s41467-024- 48063-0
15 2014 Nat Commun 15.7 The locust genome provides insight into swarm formation and long distance flight RRBS、RNA-seq、基因組 蝗蟲 DOI:10.1038/ncomms3957
16 2014 Nat Commun 15.7 Differential methylation of the TRPA1 promoter in pain sensitivity MeDIP-seq、450K、焦磷酸測序 人，全血 DOI:10.1038/ncomms3978
17 2014 Nat Commun 15.7 An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins MeDIP-seq、450K、代謝組 人，全血 DOI:10.1038/ncomms6719
18 2018 Nat Commun 15.7 Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci. MeDIP-seq、GWAS分析、 450K 人，全血 DOI:10.1038/s41467-017- 01586-1
19 2020 Nat Commun 15.7 Transcriptomic and open chromatin atlas of high-resolution anatomical regions in the rhesus macaque brain ATAC-seq、RNA-seq 恒河猴，腦組織 DOI:10.1038/s41467-020- 14368-z
20 2021 Nat Commun 15.7 The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation MeDIP-seq、Target-BS、 RRBS、450K 人 DOI:10.1038/s41467-021- 22639-6
21 2020 Nat Commun 15.7 ARTICLE JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency RNA-seq、ATAC-seq 、
ChIP-seq 		小鼠，大腦 DOI:10.1038/s41467-020- 18900-z
22 2024 CELL DEATH DIFFER 15.4 The IDH1-R132H mutation aggravates cisplatin-induced acute kidney injury by promoting ferroptosis through disrupting NDUFA1 and FSP1 interaction RRBS、RNA-seq 小鼠 細(xì)胞 doi:10.1038/s41418-024-01381-8
23 2025 SCI TRANSL MED 14.6 Interferon regulatory factor-1–expressing astrocytes are epigenetically controlled and exacerbate TBI-associated pathology in mice RRBS、oxRRBS 小鼠 DOI:10.1126/scitranslmed.adr530
24 2024 Advanced Science 14.1 Metabolic Recoding of NSUN2-Mediated m5C Modification Promotes the Progression of Colorectal Cancer via the NSUN2/YBX1/m5C-ENO1 Positive Feedback Loop RNA-BS、RNA-seq 人胚胎腎HEK
293T細(xì)胞 		doi:10.1002/advs.202309840
25 2022 J Clin Invest 13.6 Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus MeDIP-Seq 、 hMeDIP-Seq 小鼠 DOI:10.1172/JCI152345
26 2024 Chemical
Engineering Journal 		13.2 Novel strategy to understand the aerobic deterioration of
corn silage and the influence of Neolamarckia cadamba essential oil by multi-omics analysis 		宏基因組測序、宏轉(zhuǎn)錄組 腸道內(nèi)容物 DOI:10.1016/j.cej.2024.148715
27 2024 Nucleic Acids Res 13.1 Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase RNA-BS 細(xì)胞 doi.org/10.1093/nar/gkae110
28 2023 Nucleic Acids Res 13.1 A meet-up of acetyl phosphate and c-di-GMP modulates BldD activity for development and antibiotic production ChIP-seq 細(xì)菌 doi:10.1093/nar/gkad494
29 2022 Nucleic Acids Res 13.1 Schlafen 5 suppresses human immunodeficiency virus type 1 transcription by commandeering cellular epigenetic machinery ChIP-seq 小鼠，細(xì)胞 doi:10.1093/nar/gkac489
30 2025 J EXP CLIN CANC RES 12.8 NONO regulates m5C modification and alternative splicing of PTEN mRNAs to drive gastric cancer progression RNA-BS 人 細(xì)胞 DOI:10.1186/s13046-024-03260-z
31 2018 Cell discovery 12.5 DNA methylation reprogramming of functional elements during mammalian embryonic development MethylC-seq、RNA-seq 人，胚胎 DOI:10.1038/s41421-018-0039- 9
32 2025 Science Advances 12.5 Hypermethylation of DNA impairs megakaryogenesis in delayed platelet recovery after allogeneic hematopoietic stem cell transplantation WGBS、ChIP-seq、RNA-seq 人骨髓樣本 DOI：10.1126/sciadv.ads3630
33 2020 Sci Adv 12.5 β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus ChIP-qPCR、GRO-seq、 ATAC-seq、RNA-seq 人胚胎腎細(xì)胞、小鼠 DOI:10.1126/sciadv.aba1593
34 2023 Redox Biology 11.9 Epigenetic modulation of Drp1-mediated mitochondrial fission by inhibition of S-adenosylhomocysteine hydrolase promotes vascular senescence and atherosclerosis WGBS、Target-BS 小鼠血管內(nèi)皮細(xì)胞 DOI:10.1016/j.redox.2023.102828
35 2016 BRAIN 11.7 CSF1R mosaicism in a family with hereditary diffuse leukoencephalopathy with spheroids 外顯子測序、Sanger測序
、擴(kuò)增子測序 		人 DOI:10.1093/brain/aww066
36 2023 Biomarker Research 11.5 Integrative multi-Omics analysis depicts the methylome and hydroxymethylome of recurrent bladder cancers and identifies biomarkers for predicting PD-L1 expression oxRRBS RRBS RNA-seq 人，膀胱
癌組織和癌旁組織 		doi:10.21203/rs.3.rs-2456805/v1
37 2023 J Hazard Mater 11.3 Effects of thiacloprid exposure on microbiota-gut-liver axis: Multiomics mechanistic analysis in Japanese quails 微生物組16S rRNA 測序、
代謝組LC-MS測序、轉(zhuǎn)錄組RNA-seq等 		日本鵪鶉 doi:10.1016/j.jhazmat.2022.130082
38 2021 J ALLERGY CLIN IMMUN 11.2 Thymic stromal lymphopoietin epigenetically upregulates Fc receptor γ subunit–related receptors on antigen-presenting cells and induces TH2/TH17 polarization through dectin-2 oxBS 人外周血細(xì)胞 DOI:10.1016/j.jaci.2019.06.011
39 2017 Genome Med 11.2 DNA methylation changes at infertility genes in newborn twins conceived by in vitro fertilisation MeDIP-seq 人雙胞
胎，臍帶血 		DOI:10.1186/s13073-017-0413- 5
40 2018 J NEUROINFLAMM 10.1 Necrotizing enterocolitis is associated with acute brain responses in preterm pigs. RNA-seq、qPCR 早產(chǎn)豬 DOI:10.1186/s12974-018-1201-x
41 2022 Environment Internation 9.7 Genome-wide alternation and effect of DNA methylation in the impairments of steroidogenesis and spermatogenesis after PM2.5 exposure WGBS、RNA-seq、 Western Blot 小鼠，組織 DOI:10.1016/j.envint.2022.1075 44
42 2024 Cell Death & Disease 9.6 Nuclear receptor NURR1 functions to promote stemness and epithelial-mesenchymal transition in prostate cancer via its targeting of Wnt/β-catenin signaling pathway ChIP-seq分析、RNA-seq 前列腺上皮/癌細(xì)胞系 DOI:10.1038/s41419-024-06621-w
43 2012 GENOME BIOL 9.4 Differential DNA methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis MethylC-seq、 RNA-seq、qPCR 大鼠，寄
生蟲旋毛蟲 		DOI:10.1186/gb-2012-13-10- r100
44 2014 GENOME BIOL 9.4 Integrated analyses of DNA methylation and
hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5, and EOMES in human hepatocellular carcinoma 		HSMT-Seq，RNA-seq 人，HCC組織 DOI:10.1186/s13059-014-0533- 9
45 2016 GENOME BIOL 9.4 Novel regional age-associated DNA methylation changes within human common disease-associated loci MeDIP-seq 人，外周血 DOI:10.1186/s13059-016-1051- 8
46 2014 GENOME BIOL 9.4 Hypermethylation in the ZBTB20 gene is associated with major depressive disorder MeDIP-seq、RNA-seq 雙胞胎人，全血 DOI:10.1186/gb-2014-15-4-r56
47 2022 P NATL ACAD SCI USA 9.1 Mitochondrial genome undergoes de novo DNA methylation that protects mtDNA against oxidative damage during the peri-implantation window. MeDIP-seq、BS 小鼠胚胎 線粒體 DOI:10.1073/pnas.2201168119
48 2019 BIORESOURCE TECHNOL 9 Metatranscriptomics reveals microbial adaptation and
resistance to extreme environment coupling with bioleaching performance 		宏轉(zhuǎn)錄組 嗜酸性菌
株，微生物 		DOI:10.1016/j.biortech.2019.01. 117
49 2014 Neurology 8.5 TUBB4A de novo mutations cause isolated hypomyelination 全外顯子組測序 人，血液 DOI:10.1212/WNL.0000000000 000754
50 2012 Am J Hum Genet 8.1 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci 基因組、IBC 人，全血 DOI:10.1016/j.ajhg.2012.08.032
51 2011 Am J Hum Genet 8.1 Meta-analysis of Dense Genecentric Association Studies
Reveals Common and Uncommon Variants Associated with Height 		基因組、IBC 人 DOI:10.1016/j.ajhg.2010.11.007
52 2022 CHEMOSPH ERE 8.1 Longitudinal physiological and transcriptomic analyses reveal the short term and long term response of Synechocystis sp. PCC6803 to cadmium stress 原核轉(zhuǎn)錄組 聚囊藻
PCC6803 		DOI:10.1016/j.chemosphere.2022. 134727
53 2023 CHEMOSPH ERE 8.1 Effects of single and combined contamination of total
petroleum hydrocarbons and heavy metals on soil microecosystems: Insights into bacterial diversity, assembly, and ecological function 		16sRNA 土壤 doi:10.1016/j.chemosphere.2023.1402 88
54 2021 Sci Total Environ 8 Co-occurrence of antimicrobial and metal resistance genes in pig feces and agricultural fields fertilized with slurry 宏基因組 豬糞 DOI:10.1016/j.scitotenv.2021.148259
55 2022 GENOM
PROTEOM BIOINF 		7.9 Protein Lactylation and Metabolic Regulation of the Zoonotic Parasite Toxoplasma gondii ChIP-seq 弓形蟲 doi:10.1016/j.gpb.2022.09.010
56 2025 Environmental Pollution 7.3 WTAP-mediated m6A modification of Hmgb2 contributes to spermatogenic damage induced by PM2.5 exposure MeRIP-seq 小鼠睪丸組織 doi:10.1016/j.envpol.2025.125896
57 2024 J Genet Genomics 7.1 The transgenerational effects of maternal low-protein diet during lactation on offspring scRRBS、Smart-seq2 小鼠 DOI:10.1016/j.jgg.2024.04.008
58 2020 J Genet Genomics 7.1 Longitudinal epitranscriptome profiling reveals the crucial
role of N6-methyladenosine methylation in porcine prenatal skeletal muscle development 		MeRIP-seq、 RNA-seq、IGF2BP1 RIP-seq 豬，組織 https://doi.org/10.1016/j.jgg.2020. 07.003
59 2014 J
Autoimmun 		7 DNA methylation and mRNA and microRNA expression of SLE CD4t T cells correlate with disease phenotype DNA甲基化、mRNA-seq、 microRNA-seq 人，細(xì)胞 DOI:10.1016/j.jaut.2014.07.002
60 2023 Cell Reports 6.9 A bacteriocyte symbiont determines whitefly sex ratio by regulating mitochondrial function ChIP-seq 煙粉虱 doi:10.1016/j.celrep.2023.1121 02.
61 2024 Cell Reports 6.9 MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance RRBS 細(xì)胞 DOI:10.1016/j.celrep.2024.113908
62 2023 Plant Physiol 6.9 MADS-box protein PpDAM6 regulates chilling requirement-mediated dormancy and bud break in peach ChIP-seq 桃 DOI:10.1093/plphys/kiad291
63 2023 Plant Physiol 6.9 RNA m6A modification facilitates DNA methylation during maize kernel development BS-seq、MeRIP-seq 玉米 DOI:10.1093/plphys/kiad625
64 2021 Clin Transl Med 6.8 An epigenomic landscape of cervical intraepithelial neoplasia and cervical cancer using single-base resolution methylome and hydroxymethylome WGBS-seq、oxWGBS-seq
、RNA-seq 		人，宮頸組織 DOI:10.1002/ctm2.498
65 2025 Analytical Chemistry 6.7 Fragment-specific Quantification of 5hmC by qPCR via a Combination of Enzymatic Digestion and Deamination: Extreme Specificity, High Sensitivity, and Clinical Applicability ACE-seq、Target-BS 人 doi:10.1021/acs.analchem.4c05147
66 2024 J ANIM SCI BIOTECHNO 6.5 Effects of maternal methyl donor intake during pregnancy on ileum methylation and function in an intrauterine growth restriction pig model RRBS 仔豬 DOI:10.1186/s40104-023- 00970-w
67 2023 J ANIM SCI BIOTECHNO 6.5 Whole-genome transcriptome and DNA methylation
dynamics of pre-implantation embryos reveal progression of embryonic genome activation in buffaloes 		scWGBS+scRNA-seq 水牛 DOI:10.1186/s40104-023- 00894-5
68 2022 J Anim Sci Biotechnol 6.5 Coordinated transcriptional and post-transcriptional
epigenetic regulation during skeletal muscle development and growth in pigs 		WGBS、MeRIP-seq 仔豬 DOI:10.1186/s40104-022- 00791-3
69 2025 Plant Cell Environ 6.3 Multi-Omics Analysis Reveals Adaptation Strategies of Marine Diatom to Long-Term Ocean Warming: Resource Allocation Trade-Offs and Epigenetic Regulation ChIP-seq 原核藻類 DOI:10.1111/pce.15482
70 2023 Cell Mol Life Sci 6.2 Single-cell multi-omics profiling reveals key regulatory
mechanisms that poise germinal vesicle oocytes for maturation in pigs. 		scWGBS+Smart-seq2 母豬卵母細(xì)胞 DOI:10.1007/s00018-023-04873-x
71 2024 Cell Mol Life Sci 6.2 CRL4DCAF13 E3 ubiquitin ligase targets MeCP2 for
degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes 		微量WGBS、RNA-seq 小鼠胚胎 doi: 10.1007/s00018-024-05185-4
72 2023 MOL THER NUCL ACIDS 6.1 Epigenetic Inactivation of SOX30 Is Associated with Male
Infertility and Offers a Therapy Target for Non-obstructive Azoospermia 		WGBS 小鼠睪丸組織 doi:10.1016/j.omtn.2019.10.038
73 2020 ECOTOX ENVIRON SAFE 6.1 Effects of co-contamination of heavy metals and total petroleum hydrocarbons on soil bacterial community and function network reconstitution 16S rRNA、ICP 土壤 DOI:10.1016/j.ecoenv.2020.111 083
74 2020 Front Immunol 5.9 Effects of Low-Dose Antibiotics on Gut Immunity and Antibiotic Resistomes in Weaned Piglets RNA-seq、宏基因組、 ELISA 仔豬 DOI:10.3389/fimmu.2020.00903
75 2020 Front Immunol 5.9 Rapid Gut Adaptation to Preterm Birth Involves Feeding-
Related DNA Methylation Reprogramming of Intestinal Genes in Pigs 		RRBS、RNA-seq、擴(kuò)增子測序（16S rRNA） 仔豬，腸組織 DOI:10.3389/fimmu.2020.00565
76 2020 Front Immunol 5.9 Postnatal Gut Immunity and Microbiota Development Is Minimally Affected by Prenatal Inflammation in Preterm Pigs 轉(zhuǎn)錄組、宏基因組 仔豬 DOI:10.3389/fimmu.2020.00420
77 2021 Cell Biol Toxicol 5.9 Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits MeRIP-seq、RIP 小鼠 DOI:10.1007/s10565-021- 09601-4
78 2012 J Invest Dermatol 5.7 Array Comparative Genomic Hybridization of Keratoacanthomas and Squamous Cell Carcinomas: Different Patterns of Genetic Aberrations Suggest Two Distinct Entities 基因組CGH 分析 人，SCC病變組織 DOI:10.1038/jid.2012.104
79 2017 Pain 5.5 Genome-wide methylation analysis of a large population sample shows neurological pathways involvement in chronic widespread musculoskeletal pain MeDIP-seq 人，全血 DOI:10.1097/j.pain.0000000000 000880
80 2020 Mol Ecol Resour 5.5 Giant African snail genomes provide insights into molluscan whole-genome duplication and aquatic–terrestrial transition 基因組 非洲大非洲蝸牛 DOI:10.1111/1755-0998.13261
81 2024 Cells 5.2 N6-Methyladenosine RNA Modification Regulates the Differential Muscle Development in Large White and Ningxiang Pigs MeRIP-seq、RNA-seq 豬 肌肉 DOI：10.3390/cells13201744
82 2021 COMMUN BIOL 5.1 Comparative multi-omics analyses reveal differential
expression of key genes relevant for parasitism between non- encapsulated and encapsulated Trichinella 		基因組測序、WGBS、
RNA-seq 		大鼠，旋毛蟲 DOI:10.1038/s42003-021- 01650-z
83 2016 J CLIN ENDOCR METAB 5.1 Contribution of Heritability and Epigenetic Factors to Skeletal Muscle Mass Variation in United Kingdom Twins MeDIP-seq 人，全血 DOI:10.1210/jc.2016-1219
84 2025  Inflammation  5 Epigenetic Insights Into Necrotizing Enterocolitis: Unraveling Methylation-Regulated Biomarkers Target-BS 人腸道組織 DOI:10.1007/s10753-024-02054-x
85 2023 INT J MOL SCI 4.9 TET Family Members Are Integral to Porcine Oocyte Maturation and Parthenogenetic Pre-Implantation Embryogenesis Smart-seq2 豬卵母細(xì)胞 doi:10.3390/ijms241512455
86 2019 J Nutr Biochem 4.9 Inter-correlated gut microbiota and SCFAs changes upon
antibiotics exposure links with rapid body-mass gain in weaned piglet model 		16S rRNA擴(kuò)增子測序、 RNA-seq、靶向代謝組 仔豬，糞便 DOI:10.1016/j.jnutbio.2019.108 246
87 2025 BMC Plant Biology 4.8 Identification of key genes controlling anthocyanin biosynthesis in the fruits of a bud variety of Tarocco blood-orange WGBS、RNA-seq 血橙 DOI：10.1186/s12870-025-06212-7
88 2024 Front Plant Sci 4.8 Exploring the potential of Paris polyphylla var. yunnanensis pollen manipulation in modifying seed dormancy RRBS、RNA-seq 重樓花粉、種子 doi:10.3389/fpls.2024.1389357
89 2021 Front Plant Sci 4.8 Root Endophytes and Ginkgo biloba Are Likely to Share and Compensate Secondary Metabolic Processes, and Potentially Exchange Genetic Information by LTR-RTs 代謝組 銀杏葉 DOI:10.3389/fpls.2021.704985
90 2019 Front Plant Sci 4.8 Flavonoid Biosynthesis Is Likely More Susceptible to Elevation and Tree Age Than Other Branch Pathways Involved in Phenylpropanoid Biosynthesis in Ginkgo Leaves 轉(zhuǎn)錄組 銀杏葉 DOI:10.3389/fpls.2019.00983
91 2025 INT IMMUNOPHARMACOL 4.7 Metformin attenuated sepsis-related liver injury by modulating the DNA methylation and hydroxymethylation landscape RRBS+oxRRBS 大鼠 DOI:10.1016/j.intimp.2025.114748
92 2025 INVEST OPHTH VIS SCI 4.7 S100A8/A9 Promotes Dendritic Cell–Mediated Th17 Cell Response in Sj?gren's Dry Eye Disease by Regulating the Acod1/STAT3 Pathway 轉(zhuǎn)錄組 小鼠淚腺 DOI:10.1167/iovs.66.1.35
93 2024 mBio 4.7 A network of acetyl phosphate-dependent modification
modulates c-di-AMP homeostasis in Actinobacteria 		ChIP-seq 細(xì)菌紅糖多孢菌 DOI:10.1128/mbio.01411-24
94 2024 Int J Cancer 4.7 Glucocorticoid promotes metastasis of colorectal cancer via co-regulation of glucocorticoid receptor and TET2 ChIP-seq、Co-IP、RNA-seq 細(xì)胞 DOI:10.1002/ijc.35285
95 2016 Eur J Hum Genet 4.6 Lipids, obesity and gallbladder disease in women: insights from genetic studies using the cardiovascular gene-centric 50K SNP array 基因組 人 DOI:10.1038/ejhg.2015.63
96 2019 Mol Oncol 4.5 A 17 gene panel for non-small-cell lung cancer prognosis
identified through integrative epigenomic-transcriptomic analyses of hypoxia-induced epithelial-mesenchymal transition 		MeDIP-seq、hMeDIP-seq
、ChIP-seq、RNA-seq 		人，細(xì)胞 DOI:10.1002/1878-0261.12491
97 2019 J Oncol 4.5 Long Non-Coding RNA Expression Profile Associated with Malignant Progression of Oral Submucous Fibrosis lncRNA-seq  OSCC/OSF /正常口腔粘膜組織 DOI:10.1155/2019/6835176
98 2023 Front Microbiol 4.5 Dynamic changes of the gut microbial colonization in preterm infants with different time points after birth 16S rRNA 人（早產(chǎn)兒），糞便 DOI:10.3389/fmicb.2023.10784 26
99 2019 Biol Conserv 4.4 Epigenetic and transcriptional signatures of ex situ conserved golden snub-nosed monkeys (Rhinopithecus roxellana) RRBS、RNA-seq 金絲猴，糞便 https://doi.org/10.1016/j.biocon.2 019.06.021
100 2015 Clin Epigenetics 4.4 Global analysis of DNA methylation in hepatocellular carcinoma by a liquid hybridization capture-based bisulfite sequencing approach 靶向LHC-BS、RNA-seq 人，組織 DOI:10.1186/s13148-015-0121- 1
101 2018 Clin Epigenetics 4.4 Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer MeDIP-seq、hMeDIP-seq
、RNA-seq 		人，組織 DOI:10.1186/s13148-018-0458- 3
102 2023 Clin Epigenetics 4.4 Clinical characteristics and prognostic significance of DNA methylation regulatory gene mutations in acute myeloid leukemia WGBS分析及聯(lián)合分析 小鼠 DOI:10.1186/s13148-023-01474-0
103 2021 Front Cell Dev Biol 4.3 Comparative Epigenomics Reveals Host Diversity of the
Trichinella Epigenomes and Their Effects on Differential Parasitism 		全基因組測序、WGBS、
RNA-seq 		大鼠，旋毛蟲 DOI:10.3389/fcell.2021.681839
104 2024 J Cell Mol Med 4.2 Epigenomic Landscape of Human Cumulus Cells in Premature Ovarian Insufficiency Using Single-Base Resolution Methylome and Hydroxymethylome 微量WGBS、ACE-seq、Target-BS、Smart-seq2 人卵丘細(xì)胞 doi: 10.1111/jcmm.70284
105 2021 J Cell Mol Med 4.2 Exosome-derived long non-coding RNA ADAMTS9-AS2 suppresses progression of oral submucous fibrosis via AKT signalling pathway Target-BS 細(xì)胞 DOI：10.1111/jcmm.16219
106 2020 FASEB J 4.2 Prenatal inflammation suppresses blood Th1 polarization and gene clusters related to cellular energy metabolism in preterm newborns 代謝組、全轉(zhuǎn)錄組、qPCR
、ELISA 		豬模型，血液 DOI:10.1096/fj.201902629R
107 2024 iScience 4.1 The GDF6-FTO axis modulates the innate immune and inflammatory response to human respiratory syncytial virus MeRIP-seq 人細(xì)胞 DOI:10.1016/j.isci.2024.111038
108 2023 Plant Science 4.1 AtSAMS regulates floral organ development by DNA methylation and ethylene signaling pathway WGBS、RNA-seq 擬南芥 doi:10.1016/j.plantsci.2023.111767
109 2023 Plants-Basel 4.1 SDG26 Is Involved in Trichome Control in Arabidopsis thaliana: Affecting Phytohormones and Adjusting Accumulation of H3K27me3 on Genes Related to Trichome Growth and Development ChIP-seq 擬南芥 DOI:10.3390/plants12081651
110 2023 Journal of Inflammation Research 4.1 Integrated DNA Methylation and Transcriptomics Analyses of Lacrimal Glands Identify the Potential Genes Implicated in the Development of Sj?gren's Syndrome-Related Dry Eye RRBS、RNA-seq 小鼠 淚腺 DOI:10.2147/JIR.S440263
111 2023 Plants-Basel 4.1 The Sink-Source Relationship in Cucumber (Cucumis sativus L.) Is Modulated by DNA Methylation WGBS、RNA-seq 黃瓜 DOI:10.3390/plants13010103
112 2024 Toxics 4.1 Bioreactor Expansion Affects Microbial Succession of Mixotrophic Acidophiles and Bioremediation of Cadmium-Contaminated Soils 擴(kuò)增子測序 土壤 DOI:10.3390/toxics12050362
113 2021 EYE VISION 4 Intravitreal brimonidine inhibits form-deprivation myopia in guinea pigs RNA-seq 雄性豚鼠 doi:10.1186/s40662-021-00248-0
114 2024 J Dermatol Sci 4 IL-4-induced decrease in both the number and CTLA-4 expression of Treg impairs suppression of Th2 type inflammation in severe atopic dermatitis Target-BS 小鼠 細(xì)胞 DOI:10.1016/j.jdermsci.2024.03.007
115 2012 J Biotechnol 3.9 Systematic assessment of reduced representation bisulfite sequencing to human blood samples: A promising method for large-sample-scale epigenomic studies RRBS 人，血液 DOI:10.1016/j.jbiotec.2011.06.0 34
116 2024 Biomedicines 3.9 Transcriptome-Wide N6-Methyladenosine Alternations in Pulmonary Arteries of Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats and Novel Therapeutic Targets MeRIP-seq、RNA-seq 大鼠肺動脈組織 DOI:10.3390/biomedicines1202 0364
117 2016 Scientific Reports 3.9 The promoter methylomes of monochorionic twin placentas reveal intrauterine growth restriction-specific variations in the methylation patterns LHC-BS、RT-PCR 人，胎盤組織 DOI:10.1038/srep20181
118 2016 Scientific Reports 3.9 Filtrating colorectal cancer associated genes by integrated analyses of global DNA methylation and hydroxymethylation in cancer and normal tissue HMST-seq 人，CRC樣本 DOI:10.1038/srep31826
119 2016 Scientific Reports 3.9 Stochastic anomaly of methylome but persistent SRY hypermethylation in disorder of sex development in canine somatic cell nuclear transfer WGBS、WGS、MiSeq 擴(kuò)增子測序、BSP、qPCR 母狗，卵母細(xì)胞 DOI:10.1038/srep31088
120 2016 Scientific Reports 3.9 Genome-wide profiles of methylation, microRNAs, and gene expression in chemoresistant breast cancer RRBS、mRNA-seq+sRNA- seq 人，乳腺癌細(xì)胞 DOI:10.1038/srep24706
121 2016 Scientific Reports 3.9 Genome-wide landscape of DNA methylomes and their relationship with mRNA and miRNA transcriptomes in oxidative and glycolytic skeletal muscles MeDIP-seq、RNA-seq 豬，組織 DOI:10.1038/srep32186
122 2016 Scientific Reports 3.9 DNA methylation landscape of fat deposits and fatty acid composition in obese and lean pigs MeDIP-seq、Q-PCR 豬，組織 DOI:10.1038/srep35063
123 2024 Virology Journal  3.8 Vpr driving DNA methylation variation of CD4?+?T cells in HIV-1 infection WGBS 人，外周血 doi:10.1186/s12985-024-02363-5
124 2024 ACS Chem Biol 3.8 HCV 5-Methylcytosine Enhances Viral RNA Replication through Interaction with m5C Reader YBX1 RNA-BisSeq 病毒 DOI:10.1021/acschembio.4c00322
125 2011 PLoS Genet 3.7 Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes 全基因組 SNP 基因分型、
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126 2024 APPL ENVIRON MICROB 3.7 Effects of Neolamarckia cadamba leaves extract on microbial community and antibiotic resistance genes in cecal contents and feces of broilers challenged with lipopolysaccharides 宏基因組 腸道內(nèi)容物 DOI:10.1128/aem.01107-23
127 2011 BMC
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129 2013 BMC
Genomics 		3.7 Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing RRBS、dRRBS 細(xì)胞 DOI:10.1186/1471-2164-14-11
130 2014 BMC
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133 2011 Mol Cell Biochem 3.7 Regulation of cytokine expression in murine macrophages
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135 2024 Food Chem Toxicol 3.5 Triptolide exposure triggers ovarian inflammation by activating cGAS-STING pathway and decrease oocyte quality in mouse XRBS 小鼠卵母細(xì)胞 DOI:10.1016/j.fct.2024.115201
136 2022 Vet Res 3.5 The expression level of chicken telomerase reverse
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137 2021 Mol Med Rep 3.5 De novo assembly and transcriptome characterization: Novel insights into the mechanisms of primary ovarian cancer in Microtus fortis RNA-seq 東方田鼠 DOI:10.3892/mmr.2021.12580
138 2024 Andrology 3.4 Methylation of eNOS in the rat penile corpus cavernosum under different pathological states and its relationship with erectile function Target-BS 雄性大鼠海綿體組織 DOI:10.1111/andr.13465
139 2018 Frontiers in physiology 3.4 The Use of Targeted Next Generation Sequencing to Explore Candidate Regulators of TGF-β1's Impact on Kidney Cells MeDIP-seq、miRNA-seq、 RNA-seq、ChIP-Seq 小鼠，細(xì)胞 DOI:10.3389/fphys.2018.01755
140 2014 Frontiers in physiology 3.4 Trichinella spiralis, potential model nematode for epigenetics and its implication in metazoan parasitism DNA甲基化 小鼠，螺旋旋毛蟲 DOI:10.3389/fphys.2013.00410
141 2021 J Neurosci Res 3.4 Epitranscriptomic m6A regulation following spinal cord injury MeRIP-seq、RNA-seq、 qRT-PCR 斑馬魚/小鼠，細(xì)胞 DOI:10.1002/jnr.24763
142 2015 Res Microbiol 3.4 Comparative metagenomics reveals microbial community differentiation in a biological heap leaching system 宏基因組 礦石 DOI:10.1016/j.resmic.2015.06.0 05
143 2021 AM J PHYSIOL-GASTR L 3.3 Subclinical necrotizing enterocolitis-induced systemic immune suppression in neonatal preterm pigs 轉(zhuǎn)錄組 新生早產(chǎn)豬模型 DOI:10.1152/ajpgi.00408.2020
144 2017 Stem Cells Int 3.3 Vitrification of Rhesus Macaque Mesenchymal Stem Cells and the Effects on Global Gene Expression. RNA-seq、qRT-PCR 獼猴、骨髓細(xì)胞 DOI:10.1155/2017/3893691
145 2022 Pathogens 3.3 Intestinal and Mucosal Microbiome Response to Oral Challenge of Enterotoxigenic Escherichia coli in Weaned Pigs 非靶蛋白質(zhì)組學(xué)和16S擴(kuò)增子測序 斷奶豬 DOI:10.3390/pathogens110201 60
146 2020 BMC
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148 2015 Hum Mol Genet 3.2 Mutation in mitochondrial ribosomal protein S7 (MRPS7)
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149 2013 Epigenetics 3.2 Integrated detection of both 5-mC and 5-hmC by high-
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151 2021 Pediatr Res 3.1 Blood transcriptomic markers of necrotizing enterocolitis in preterm pigs. 轉(zhuǎn)錄組 早產(chǎn)仔豬
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152 2015 J PHARMACEUT BIOMED 3.1 A transcription/translation-based gene signature predicts resistance to chemotherapy in breast cancer 細(xì)胞 doi:10.1016/j.jpba.2014.10.018
153 2023 BMC Oral Health 3.1 Low-dose arecoline regulates distinct core signaling pathways in oral submucous fibrosis and oral squamous cell carcinoma dRRBS 細(xì)胞 DOI：10.1186/s12903-023-02887-2
154 2014 Genomics 3 Direct ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells ChIP-BS-seq、ChIP-seq、 RNA-seq 人，細(xì)胞 DOI:10.1016/j.ygeno.2013.12.00 6
155 2025 Genomics 3 Comparative effects of arecoline, caffeine, and nicotine on transcription level in the nucleus accumbens of mice smart-seq2 小鼠 DOI:10.1016/j.ygeno.2025.110986
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157 2018 DNA Res 2.9 Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs RRBS、16S rRNA測序 仔豬，糞便 DOI:10.1093/dnares/dsy001
158 2022 Neuroscience 2.8 Epitranscriptomic Analysis of N6-methyladenosine in Infant Rhesus Macaques after Multiple Sevoflurane Anesthesia MeRIP-seq 獼猴 DOI:10.1016/j.neuroscience.202 1.11.030
159 2024 Front Genet 2.8 Regulatory role of N6-Methyladenosine on skeletal muscle development in Hu sheep MeRIP-seq 綿羊組織 DOI:10.3389/fgene.2024.1449144
160 2021 Front Genet 2.8 Diet-Dependent Changes of the DNA Methylome Using a G? ttingen Minipig Model for Obesity LHC-BS、代謝組 哥廷根小型豬模型 DOI:10.3389/fgene.2021.63285 9
161 2023 Front Genet 2.8 Unidirectional alteration of methylation and
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162 2021 Front Genet 2.8 Genome-wide DNA Methylation and Hydroxymethylation Changes Revealed Epigenetic Regulation of Neuromodulation and Myelination in Yak Hypothalamus oxRRBS+RRBS 牦牛，組織 DOI:10.3389/fgene.2021.59213 5
163 2022 Genes 2.8 Effect of Humantenine on mRNA m6A Modification and Expression in Human Colon Cancer Cell Line HCT116 MeRIP-seq、 RNA-seq 人/線蟲 https://doi.org/10.3390/genes1 3050781
164 2015 NEUROMUSCULAR DISORD 2.8 Delayed diagnosis of congenital myasthenia due to associated mitochondrial enzyme defect WES、Sanger測序 人 DOI:10.1016/j.nmd.2014.11.017
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169 2015 Epigenomics 2.6 Improved tagmentation-based whole-genome bisulfite
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170 2013 PLoS ONE 2.6 Sorafenib Inhibits Epithelial-Mesenchymal Transition through an Epigenetic-Based Mechanism in Human Lung Epithelial Cells ChIP-seq、ChIP-qPCR 人，細(xì)胞 DOI:10.1371/journal.pone.0064 954
171 2011 PLoS ONE 2.6 A Systematic Analysis on DNA Methylation and the Expression of Both mRNA and microRNA in Bladder Cancer MMSDK甲基化測序、轉(zhuǎn)錄組 人，組織 DOI:10.1371/journal.pone.0028 223
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173 2021 PLoS ONE 2.6 Millet-based supplement restored gut microbial diversity of acute malnourished pigs 16S rRNA 豬 DOI:10.1371/journal.pone.0250 423
174 2020 BMC Genomic Data 2.5 Multi-omics profiling highlights lipid metabolism alterations in pigs fed low-dose antibiotics LHC-BS、RNA-seq、脂質(zhì)組分析 豬 DOI:10.1186/s12863-020- 00918-3
175 2013 BMC Genomic Data 2.5 High-throughput sequencing of methylated cytosine enriched by modification-dependent restriction endonuclease MspJI MspJI-seq 擬南芥 DOI:10.1186/1471-2156-14-56
176 2021 Hereditas 2.5 Regulation of DNA methylation on key parasitism genes of Cysticercus cellulosae revealed by integrative epigenomic- transcriptomic analyses WGBS、RNA-seq 囊尾蚴 DOI:10.1186/s41065-021- 00195-9
177 2016 CLIN GENET 2.3 Utility of next-generation sequencing technologies for the efficient genetic resolution of haematological disorders WES 人，血液 DOI:10.1111/cge.12573
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180 2018 Anim Genet 2.1 Identification of the mutation causing progressive retinal atrophy in Old Danish Pointing Dog. 全基因組測序 犬 DOI:10.1111/age.12659
181 2015 BMC
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182 2012 Parasitol Res 2 Inhibition of mammalian muscle differentiation by excretory secretory products of muscle larvae of Trichinella spiralis in vitro 代謝組 螺旋旋毛
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185 2017 TRANSPL P 0.8 Changes in DNA Methylation of Glucocorticoid-Induced
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